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VOLUME 3 , ISSUE 1 ( 2013 ) > List of Articles


Photodynamic Therapy (Part 1: Applications in Dentistry)

Suchetan Pradhan, Yogesh Doshi, Nikhil Vishwas Khandge, Ishan Dhruva

Citation Information : Pradhan S, Doshi Y, Khandge NV, Dhruva I. Photodynamic Therapy (Part 1: Applications in Dentistry). Int J Laser Dent 2013; 3 (1):7-13.

DOI: 10.5005/jp-journals-10022-1029

License: CC BY-NC 4.0

Published Online: 00-04-2013

Copyright Statement:  Copyright © 2013; Jaypee Brothers Medical Publishers (P) Ltd.


Aim: To overview the effectiveness of photodynamic therapy (PDT) along with different types of photosensitizers and the lasers associated with them. Background: Administration of drugs for oral infections and pathologies are accompanied with a lot of limitations like lack of patient compliance, microbial resistance in the biofilm, systemic side effects, failure on the antibiotics to act on non-perfused areas, allergy and the limitation of spectrum of microorganisms affected. To overcome this, an effective and an alternative therapy needs to replace the conventional treatment. Indians since ancient past have been using the extracts of Psoralea corylifolia which contains furocoumarins, given orally, and followed by exposure to sunlight in order to treat vitiligo. Thus, PDT was investigated in the past as a promising alternative if not replacement for the conventional treatment. Clinical significance: It has been seen that various combinations of photosensitizer and lasers are effective against a broad spectrum of microorganisms. Porphyrin photosensitizers and temoporfin have been used successfully in the past against premalignant and malignant intraoral lesions. They are excellent options for palliative treatment for cases refractory to conventional therapy. Phenothiazinium photosensitizers like methylene blue and toluidine blue have shown to be effective against bacterias, viruses and fungal infections. Hence, they are effective tools for the treatment of refractory periodontics and endodontic infections. Conclusion: With the revolution of lasers in the field of dentistry and oncology, a new minimally invasive and precise approach towards the pathology is being developed. However, further research needs to be done in terms of development of newer formulations and dosimetry for more consistent results free of side effects.

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  1. Amano A. Disruption of epithelial barrier and impairment of cellular function by Porphyromonas gingivalis. Front Biosci 2007;12:3965-74.
  2. Meyer DH, Sreenivasan PK, Fives-Taylor PM. Evidence for invasion of a human oral cell line by Actinobacillus actinomycetemcomitans. Infect Immun 1991;59:2719-26.
  3. Rolph HJ, Lennon A, Riggio MP, et al. Molecular identification of microorganisms from endodontic infections. J Clin Microbiol 2001;39:3282-89.
  4. Haapasalo M, Ørstavik D. In vitro infection and disinfection of dentinal tubules. J Dent Res 1987;66:1375-79.
  5. Foschi F, Cavrini F, Montebugnoli L, et al. Detection of bacteria in endodontic samples by polymerase chain reaction assays and association with defined clinical signs in Italian patients. Oral Microbiol Immunol 2005;20:289-95.
  6. Walker CB. The acquisition of antibiotic resistance in the periodontal microflora. Periodontol 2000 1996;10:79-88.
  7. Tunger O, Dinc G, Ozbakkaloglu B, Atman C, Algun U. Evaluation of rational antibiotic use. Int J Antimicrob Agents 2000;15:131-35.
  8. Boyle-Vavra S, Labischinski H, Ebert CC, Ehlert K, Daum RS. A spectrum of changes occurs in peptidoglycan composition of glycopeptide-intermediate clinical Staphylococcus aureus isolates. Antimicrob Agents Chemother 2001;45:280-87.
  9. Roland KL, Esther CR, Spitznagel JK. Isolation and characterization of a gene, pmrD, from Salmonella typhimurium that confers resistance to polymixin when expressed in multiple copies. J Bacteriol 1994;176:3589-97.
  10. Harder KJ, Nikaido H, Matsuhashi M. Mutants of Escherichia coli that are resistant to certain beta-lactam compounds lack the ompF porin. Antimicrob Agents Chemother 1981;20:549-52.
  11. Allison RR, Mang TS, Wilson BD. Photodynamic therapy for the treatment of nonmelanomatous cutaneous malignancies. Semin Cutan Med Surg 1998;17(2):153-63.
  12. Bonnett R, Berenbaum M. Porphyrins as photosensitizers. Ciba Found Symp 1989;146:40-53.
  13. Dougherty TJ, Henderson BW, Schwartz S, et al. Historical perspective. In: Henderson BW, Dougherty TJ (Eds). Photodynamic therapy. New York: Marcel Dekker 1992;1-15.
  14. Llano J, Raber J, Eriksson LA. Theoretical study of phototoxic reactions of psoralens. J Photochem Photobio A: Chem 2003;154:235-43.
  15. von Tappeiner H. Zur kenntis der lichtwirkenden (fluoreszierenden) stoffe. Dtsch Med Wochen 1904;1:579-80.
  16. Takasaki AA, Aoki A, Mizutani K, Schwarz F, Sculean A, Wang C, et al. Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases. Periodontology 2000 2009;51:1-32.
  17. Konopka K, Goslinski T. Photodynamic therapy in dentistry. J Dent Res 2007;86:694.
  18. Hassan T, Parrish JA. Photodynamic therapy of cancer. In: Holland JF, Frei EI, Bast RJC, Kufe DW, Morton DL, Weisehselbaum RR (Eds). Cancer medicine (4th ed). Baltimore, MD: The William & Wilkins Co 1996; 739-51.
  19. Pfitzner A. Bacterial killing by photodynamic therapy. J Periodontol 2006;75:1343-49.
  20. Allison RR, Downie GH, Cuenca R, Hu X-H, Childs CJH, Sibata CH. Photosensitizers in clinical PDT. Photodiag Photodyn Ther 2004;1:27-42.
  21. Wainwright M. Photodynamic antimicrobial chemotherapy (PACT). J Antimicrob Chemother 1998;42:13-28.
  22. Wilson M. Photolysis of oral bacteria and its potential use in the treatment of caries and periodontal disease. J Appl Bacteriol 1993;75:299-306.
  23. Malik Z, Hanania J, Nitzan Y. Bactericidal effects of photoactivated porphyrins—an alternative approach to antimicrobial drugs. J Photochem Photobiol B 1990;5:281-93.
  24. Yoshikawa TT. Antimicrobial resistance and aging: Beginning of the end of the antibiotic era? J Am Geriatr Soc 2002;50: s226-29.
  25. Hancock RE, Bell A. Antibiotic uptake into Gram-negative bacteria. Eur J Clin Microbiol Infect Dis 1988;7:713-20.
  26. Livermore DM. Antibiotic resistance in staphylococci. Int J Antimicrob Agents 2001;16:3-10.
  27. Agarwal R, Athar M, Urban SA, Bickers DR, Mukhtar H. Involvement of singlet oxygen in chloroaluminum phthalocyanine tetrasulfonate-mediated photoenhancement of lipid peroxidation in rat epidermal microsomes. Cancer Lett 1991;56:125-29.
  28. Phoenix DA, Sayed Z, Hussain S, Harris F, Wainwright M. The phototoxicity of phenothiazinium derivates against Escherichia coli and Staphylococcus aureus. FEMS Immun Med Microbiol 2003;39:17-22.
  29. Garcez AS, Nunez SC, Hamblin MR, Ribeiro MS. Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion. J Endod 2008;34:138-42.
  30. George S, Kishen A. Influence of photosensitizer solvent on the mechanisms of photoactivated killing of Enterococcus faecalis. Photochem Photobiol 2008;84:734-40.
  31. Bergmans L, Moisiadis P, Huybrechts B, Van Meerbeek B, Quirynen M, Lambrechts P. Effect of photo-activated disinfection on endodontic pathogens ex vivo. Int Endod J 2008;41:227-39.
  32. Bonsor SJ, Nichol R, Reid TM, Pearson GJ. An alternative regimen for root canal disinfection. Br Dent J 2006;201:101-05.
  33. Tegos GP, Anbe M, Yang C, et al. Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivation. Antimicrob Agents Chemother 2006;50:1402-10.
  34. Fimple JL, Fontana CR, Foschi F, et al. Photodynamic treatment of endodontic polymicrobial infection in vitro. J Endod 2008;34:728-34.
  35. Demidova TN, Hamblin MR. Effect of cell-photosensitizer binding and cell density on microbial photoinactivation. Antimicrob Agents Chemother 2005;49:2329-35.
  36. Fonseca MB, Junior PO, Pallota RC, Filho HF, Denardin OV, Rapoport A, et al. Photodynamic therapy for root canals infected with Enterococcus faecalis. Photomed Laser Surg 2008 Jun;26(3):209-13.
  37. Lambrechts P, Huybrechts B, Moisiadis P, Bergmans L, Mattar D, Teughels W, et al. Photoactivated disinfection: Paintball endodontics. Roots 2007;2:28-43.
  38. Fonseca MB, Júnior PO, Pallota RC, Filho HF, Denardin OV, Rapoport A, et al. Photodynamic therapy for root canals infected with Enterococcus faecalis. Photomed Laser Surg 2008 Jun;26(3):209-13.
  39. George S, Kishen A. Advanced noninvasive light-activated disinfection: Assessment of cytotoxicity on fibroblast versus antimicrobial activity against Enterococcus faecalis. J Endod 2007;33:599-602.
  40. Xu Y, Young MJ, Battaglino RA, et al. Endodontic antimicrobial photodynamic therapy: Safety assessment in mammalian cell cultures. J Endod 2009;35:1567-72.
  41. DeRosa MC, Crutchley RJ. Photosensitized singlet oxygen and its applications. Coordination Chemistry Reviews 2002;233- 234:351-71.
  42. Garcez AS, Nunñez SC, Hamblim MR, Suzuki H and Ribeiro MS. Photodynamic therapy associated with conventional endodontic treatment in patients with antibiotic-resistant microflora: A preliminary report. J Endod 2010 Sep;36(9): 1463-69.
  43. Brown SB, Brown EA, Walker I. The present and future role of photodynamic therapy in cancer treatment. Lancet Oncol 2004;5:497-508.
  44. Huang Z. A review of the progress in clinical photodynamic therapy. Technol Cancer Res Treatment 2005;4:283-93.
  45. Zanin ICJ, Maristela ML, Rodrigues LKA, Pimenta LAF, Hofling JF, Goncalves RB. Photosensitization of in vitro Biofilms by toluidine blue O combined with a light emitting diode. Eur J Oral Sci 2006;114; 64-69.
  46. Overman PR. Biofilm: A new view of plaque. J Contemp Dent Pract 2000;1(3):18-29.
  47. Shibli JA, Martins MC, Nociti FH Jr, Garcia VG, Marcantonio E Jr. Treatment of ligature-induced peri-implantitis by lethal photosensitization and guided bone regeneration: A preliminary histologic study in dogs. J Periodontol 2003 Mar;74(3):338-45.
  48. Zitzmann NU, Berglundh T, Ericsson I, Lindhe J. Spontaneous progression of experimentally induced peri-implantitis. J Clin Periodontol 2004;31:845-49.
  49. Rinke S, Ohl S, Ziebolz D, Lange K, Eickholz P. Rinke S, et al. Prevalence of peri-implant disease in partially edentulous patients: A practice-based cross-sectional study. Clin Oral Implants Res 2011;22:826-33.
  50. Renvert S, Persson GR. Periodontitis as a potential risk factor for peri-implantitis. J Clin Periodontol 2009;36:10:9-14.
  51. Cho-Yan Lee J, Mattheos N, Nixon KC, Ivanovski S. Residual periodontal pockets are a risk indicator for peri-implantitis in patients treated for periodontitis. Clin Oral Implants Res 2012; 23:323-33.
  52. Ferreira SD, Silva GL, Cortelli JR, Costa JE, Costa FO. Prevalence and risk variables for peri-implant disease in Brazilian subjects. J Clin Periodontol 2006;33:929-35.
  53. Turkyilmaz I. One-year clinical outcome of dental implants placed in patients with type 2 diabetes mellitus: A case series. Implant Dent 2010;19:323-29.
  54. Laine ML, Leonhardt A, Roos-Jansåker AM, Peña AS, van Winkelhoff AJ, Winkel EG, Renvert S. IL-1RN gene polymorphism is associated with peri-implantitis. Clin Oral Implants Res 2006;17:380-85.
  55. Albrektsson T, Wennerberg A. Oral implant surfaces: Part 1— review focusing on topographic and chemical properties of different surfaces and in vivo responses to them. Int J Prosthodont 2004;17:536-43.
  56. Wennerberg A, Albrektsson T. On implant surfaces: A review of current knowledge and opinions. Oral Maxillofac Implants 2010;25:63-74.
  57. Teughels W, Van Assche N, Sliepen I, Quirynen M. Effect of material characteristics and/or surface topography on biofilm development. Clin Oral Implants Res 2006;17(Suppl 2):68-81.
  58. Karoussis IK, Bragger U, Salvi GE, Burgin W, Lang NP. Effect of implant design on survival and success rates of titanium oral implants: A 10-year prospective cohort study of the ITI Dental Implant System. Clin Oral Implants Res 2004;15:8-17.
  59. Renvert S, Polyzois I, Claffey N. How do implant surface characteristics influence peri-implant disease? J Clin Periodontol 2011;38(Suppl 11):214-22.
  60. Lang NP, Tonetti M. Peri-implantitis: Etiology, pathogenesis, prevention and therapy, In: Dental implant complications etiology, prevention, and treatment: Forum SJ (Ed). Blackwell Publishing, West Sussex, United Kingdom 2010.
  61. Esposito M, Grusovin MG, Maghaireh H, Coulthard P, Worthington HV. Interventions for replacing missing teeth: Management of soft-tissues for dental implants. Cochrane Database Syst Rev 2007;18.
  62. Bouri A Jr, Bissada N, Al-Zahrani MS, Faddoul F, Nouneh I. Width of keratinized gingiva and the health status of the supporting tissues around dental implants. Int J Oral Maxillofac Implants 2008;23:323-26.
  63. Miyata T, Kobayashi Y, Araki H, Ohto T, Shin K. The influence of controlled occlusal overload on peri-implant tissue. Part 3: A histologic study in monkeys. Int J Oral Maxillofac Implants 2000;15:425-31.
  64. Baron M, Haas R, Baron W, Mailath-Pokorny G. Peri-implant bone loss as a function of tooth-implant distance. Int J Prosthodont 2005;18:427-33.
  65. Dvorak G, Arnhart C, Heuberer S, Huber CD, Watzek G, Gruber R. Peri-implantitis and late implant failures in postmenopausal women: A cross-sectional study. J Clin Periodontol 2011;38: 950-55.
  66. Shabestari GO, Shayesteh YS, Khojasteh A, Alikhasi M, Moslemi N, Aminian A, et al. Implant placement in patients with oral bisphosphonate therapy: A case series. Clin Implant Dent Relat Res 2010; 12:175-80.
  67. Serino G, Turri A. Extent and location of bone loss at dental implants in patients with peri-implantitis. J Biomech 2011; 11:267-71.
  68. Renvert S, Polyzois I, Maguire R. Reosseointegration on previously contaminated surfaces: A systematic review. Clin Oral Implants Res Sep 2009;20(Suppl 4):216-27.
  69. Niemz MH. Laser-tissue interactions-fundamentals and applications. Auage, Springer Verlag, Berlin-New York, 2003;45-149.
  70. Walsh LJ. The current status of laser applications in dentistry. Aust Dent J, 2003;48:146-55.
  71. Welch AJ. The thermal response of laser irradiated tissue. IEEE J Quant Electron 1984;20:1471-81.
  72. Gutknecht N, et al. Proceedings of the 1st International Workshop of Evidence Based Dentistry on Lasers in Dentistry. Quintessence Publishing Co. Ltd. 2007.
  73. Duck FA. Physical properties of tissue. Academic Press London- Toronto, 1990.
  74. Ishii J, Fujita K, Komori T. Laser surgery as a treatment for oral leukoplakia. Oral Oncol 2003;39(8):759-69.
  75. Katzir A. Lasers and optical fibers in medicine. Academic Press, Inc, San Diego-Boston 1993.
  76. Nathan MI, Dumke WP, Burns G, Dill Jr FH, Lasher G. Stimulated emission of radiation from GaAs p-n junctions. Appl Phys Lett 1962;1(3):62-64.
  77. Prahl SA. Optical absorption of hemoglobin. Oregon Medical Laser Center: index.html
  78. Strassl M, Kassenbacher A, Wintner E. Ultrashort laser pulses in dentistry. J Oral Laser Appl 2002;2(4):213-22.
  79. Stabholz A, Zeltzser R, Sela M, Peretz B, Moshonov J, Ziskind D. The use of lasers in dentistry: Principles of operation and clinical applications. Compend 2003;24:811-24.
  80. Kreisler M, Daublander M, Willershausen-Zonnchen B, d‘Hoedt B. Effect of diode laser irradiation on the survival rate of gingival fibroblast cell cultures. Laser Surg Med 2001a;28(5):445-50.
  81. Rastegar S, Jacques SL, Motamedi M, Kim BM. Theoretical analysis of equivalency of high- power diode laser and Nd:YAG laser for coagulation. Lasers in Dentistry, SPIE 1646:150-60, 1992.
  82. Theodoro LH, Haypek P, Bachmann L, Garcia VG, Sampaio JE, Zezell DM, Eduardo C de P. Effect of Er:YAG and diode laser irradiation on the root surface: Morphological and thermal analysis. J Periodontol 2003;74(6):838-43.
  83. White JM, Gekelman D, Shin K, Park X, Swenson T, Rouse B, Tran K, Bullard S, Scott- Beckles B, Oto MJSB, Yamamoto A. Laser interaction with dental soft tissues: What do we know from our years of applied scientific research? Lasers in Dentistry, SPIE 2002;4610:39-48.
  84. Adams TC, Pang PK. Lasers in Aesthetic Dentistry. Dent Clin North Am 2004;48:833-60.
  85. Bach G, Neckel C, Mall C, Krekeler G. Conventional versus laser- assisted therapy of peri-implantitis: A five year comparative study. Implant Dent 2000;9:247-51.
  86. Clayman L, Kuo PC. Soft tissue excision techniques. In Clayman L, Kuo P. Lasers in Maxillofacial Surgery and Dentistry. Thieme Publ, Stuttgart 1997;63-83.
  87. Convissar RA, Diamond LB, Fazekas CD. Laser treatment of orthodontically induced gingival hyperplasia. Gen Dent 1996;44(1):47-51.
  88. Goharkay K, Moritz A, Wilder-Smith P, Schoop U, Kluger W, Jakolitsch S, Sperr W. Effects on oral soft tissue produced by a diode laser in vitro. J Oral Surg 1978;36:932-37.
  89. Olbricht SM, Stern RS, Tang SV, Noe JM, Arndt KA. Complications of cutaneous laser surgery: A survey. Arch Dermatol 1987;123(3):345-49.
  90. Pinheiro AL, Limeira Jr FA, Gerbi MEM, Ramalho LMP. Effect of 830 nm laser light on the repair of bone defects grafted with inorganic bovine bone and decalciûed cortical osseous membrane. J Clin Laser Med Surg 2003;21(6):383-88.
  91. Romanos GE. Atlas der chirurgischen Laserzahnheilkunde. Urban und Fischer Verlag, München 1999.
  92. Romanos GE, Nentwig GH. Present and future of lasers in oral soft tissue surgery: Clinical applications. J Clin Laser Med Surg 1996;14(4):179-84.
  93. Strauss RA. Laser management of discrete lesions. In : Laser applications in oral maxillofacial surgery. (Eds) Catone G A, Alling C C, Saunders, Philadelphia, 1997
  94. White JM, Goodis HE, Horton J, Gold S. Current status of lasers in soft tissue dental surgery. J Periodontol 1994;65(7):733-35.
  95. Yousuf A, Hossain M, Nakamura Y, Yamada Y, Kinoshita J, Matsumoto K. Removal of gingival melanin pigmentation with the semiconductor diode laser: A case report. J Clin Laser Med Surg 2000;18:263-66.
  96. Zeinoun T, Nammour S, Dourov N, Aftimos G, Luomanen M. Myofibroblasts in healing laser excision wounds. Lasers Surg Med 2001;28:74-79.
  97. Al-Watban FA, Zhang XY. The comparison of effects between pulsed and CW lasers on wound healing. J Clin Laser Med Surg 2004;22(1):15-18.
  98. Gutknecht N, Gogswaardt D, Conrads G, Apel C, Schubert C, Lampert F. Diode laser radiation and its bactericidal effect in root canal wall dentin. J Clin Las Med Surg 2000;57:57-60.
  99. Parkins F. Lasers in pediatric and adolescent dentistry. Dent Clin N Amer 2000;44:821-30.
  100. Santaella MR, Braun A, Matson E, Frentzen M. Effect of diode laser and fluoride varnish on initial surface demineralisation of primary dentition enamel: An in vitro study. Int J Paed Dent 2004;14:199-203.
  101. Tuner J, Hode L. The laser therapy handbook. Grängesberg 2004;231.
  102. Gherlone EF, Maiorana C, Grassi RF, Ciancaglini R, Cattoni F. The use of 980 nm diode and 1064 nm Nd: YAG laser for gingival retraction in fixed prostheses. J Oral Laser Applications 2004;4:183-90.
  103. Glauche CE, de Freitas PM, Vieira ND, Marques JL. Qualitative microanalysis of ions and ultrastructuralchanges in dentin exposed to laser irradiation. Lasers Surg Med 2005;36(4): 334-39.
  104. Gutknecht N, Zimmermann R, Lampert F. Lasers in periodontology: State of the art. J Oral Laser Applications 2001a;1:169-79.
  105. Kreisler M, Haj HA, d‘Hoedt B. Clinical efficacy of semiconductor laser application as an adjunct to conventional scaling and root planning. Lasers Surg Med 2005;37:350-55.
  106. Mester E, Spiry T, Szende B, Tota JG. Effect of laser rays on wound healing. Am J Surg 1971;22:532-35.
  107. Patruta S, Franz A, Beer F, Goharkhay K, Sperr W, Moritz A. In vitro stimulatory effect of diode laser on the secretion of tissue inhibitor of matrix mealloproteinases 1(TIMP-1) in human gingival fibroblast: A preliminary report. J Oral Laser Applications 2004;4(3):167-70.
  108. Silveira LB, Silveira JB, Ribeiro MS, Garrocho AA, Novelli MD, Marigo H, Growth EB, et al. In vivo study on mast cells behavior following low intensity visible and near infrared laser radiation (abstract 304). Lasers Surg Med 2002;82.
  109. Bach G, Koch HK, Hellerich U, Venzke T. Konventionelle Diodenlaser versus Hochpulstechnik. Laser Journal 1/2008:18-20.
  110. Deppe H, Horch HH. Laseranwendungen in der chirurgischen Zahn-,Mund-und Kieferheilkunde. Laser Zahnheilkunde 2007;4:219-22.
  111. Horch HH, Deppe H. Laser anwendungen im Mund-Kiefer- Gesichtsbereich. In Horch HH: Mund-Kiefer-Gesichtschirurgie. München: Elsevier 2007;797-820.
  112. Roodenburg JL, Witjes MJ, deVeld DC; Tan IB, Nauta JM: Lasers in dentistry. Use of lasers in oral and maxillofacial surgery. Ned Tijdschr Tandheelkd 2002;109:470.
  113. Maiorana C, Salina S. Oral soft tissue pathologies: Long-term evaluation after laser treatment. J Oral Laser Appl 2001;1:20.
  114. Crippa R. Report on 103 cases of precancerous and other oral lesions treated with a diode laser. J Oral Laser Appl 2001;1:26.
  115. Bach G. Er:YAG versus Diode-Zwei Wellenlängen made in Baden-Württemberg. Laser Zahnheilkunde 2007;4:283-87.
  116. Andersen K. Laser technology- a surgical tool of the past, present and future. Aorn J 2003;78:794-802.
  117. Eichler J, Schneeweiss-Wolter C. Wirkung von Laserstrahlung auf Gewebe. MTA 1999;14:255.
  118. McKenzie AL. Physics of thermal processes in laser- tissue interaction. Phys Med Biol 1990;35:1175-209.
  119. Sullins KE. Diode laser and endoscopic laser surgery. Vet Clin North Am Small Anim Pract 2002;32:639-648.
  120. Svaasand LO, Boerslid T, Oeveraasen M. Thermal and optical properties of living tissue: Application to laser-induced hyperthermia. Lasers Surg Med 1985;5:589-602.
  121. Welch AJ, Motamedi M, Rastegar S, LeCarpentier GL, Jansen D. Laser thermal ablation. Photochem. Photobiol 1991;53: 815-23.
  122. Lippert BM, et al. Wound healing after laser treatment of oral and oropharyngeal cancer. Lasers Med Sci. 2003;18(1):36-42.
  123. Grossenbacher R. Laser surgery in the oral cavity. J Clin Laser Med Surg 1992;10(1):19-21.
  124. Guttenberg SA, Emery RW. Laser resurfacing and oral and maxillofacial surgeons. Dermatol. Surg 1999;25(6):519.
  125. Coleton S. Laser treatment of atypical oral pigmentation. A case report. NY State Dent J 2006;72(2):22-23.
  126. Damante CA, et al. Histomorphometric study of the healing of human oral mucosa after gingivoplasty and low-level laser therapy. Lasers Surg Med 2004;35(5):377-84.
  127. Eichler J, Eichler HJ. Laser. Springer Verlag, Berlin- Heidelberg- New York 1991.
  128. Manni J. Surgical diode lasers. J Clin Laser Med Surg 1992;10: 377-80.
  129. Pick RM, Powel GL. Lasers in dentistry, soft tissue procedures. Dent Clin North Am 1993;37:281-97.
  130. Scherer H, Fuhere A, Hopf J. Current status of laser surgery of benign diseases in the area of soft palate. Laryngol Rhinol Otol 1994;73:14-18.
  131. Morita T, Okamura Y, Ookub K, et al. A new instrument for hemostatic vascular management in endoscopic surgery: Diode laser(STATLaser-SDL) and it‘s hand piece (Dual Hook). J Clin Laser Med Surg 1999;17:57-61.
  132. Claus PN. Comparative study on CW mode versus pulsed mode in AlGaAs diode lasers. SPIE Proc 2001;4249:44-49.
  133. Krause F, Frentzen M. Dioden- Laser in der zahnmedizinischen Anwendung. DGL Zeitschrift für Laserzahnheilkunde 2007;3/ 07:151-58.
  134. Coluzzi DJ. Lasers and soft tissue curettage: An update. Compend Contin Educ Dent 2002;23:1104-111.
  135. Dederich DN. Laser curettage: An overview. Compend Contin Educ Dent 2002;23:1097-103.
  136. Schwarz F, Sculean A, Berakdar M, Szathmari L, Geoerg T, Becker J. In vivo and in vitro effects of an Er:YAG laser, a diode laser, and scaling and root-planning on periodontally diseased root surfaces: A comparative histologic study. Lasers Surg Med 2003;32:359-66.
  137. Fontana CR, Kurachi C, Mendonca CR, Bagnato VS. Temperature variation at soft periodontal and rat bone tissue during a medium- power diode laser exposure. Photomed Lasres Surg 2004;22:519-22.
  138. Gold SJ, Vilardi MA. Pulsed laser beam effect on gingiva. J Clin Periodontol 1994;21(6):391-96.
  139. Borrajo JL, Varela LG, Castro LG, Rodriguez-Nunez I, Torreira MG: Diode laser (980 nm) as an adjunct to scaling and root planning. Photomed Laser Surg 2004;22:509-12.
  140. Kreisler M, Al Haj H, Daublander M, Gotz H, Duschner H, Willershausen B, D‘Hoedt B. Effect of diode laser irradiation on root surface in vitro. J Clin Laser Med Surg 2002;20:63-69.
  141. Meister J, Franzen R. Dentale Lasersysteme Teil II: Der Dioden- Laser. DGL Zeitschrift für Laserzahnheilkunde 2007;3/07: 185-89.
  142. Alam T, Dawasaz AA, Thukral N, Jangam D. Surgical diode laser excision for peripheral cemento-ossifying fibroma: A case report and literature review. J Oral Laser Applications 2008;8:43- 49.
  143. Convissar RA. An overview of laser wavelength used in dentistry. Dent Clin North Am 2000;44:753-765.
  144. Kreisler M, Meier C, Stender E, Daubländer M, Willershausen- Zönnchen B, de Hoedt B. Effect of diode laser irradiation on the attachment rate of periodontal ligament cells: An in vitro study. J Periodontol Oct 2001;72(10):1312-17.
  145. Black P. Der Dentallaser in der oralen Chirurgie-Masterthese- Teil2 Laser Journal 1/2007: 16-21, 2007 146. Van Hillegersberg R: Fundamentals of Laser Surgery Eur J Surg Jan 1997;163(1): 3-12.
  146. Haina D, Landthaler M, Braun-Falco O, Waidelich W. Comparison of the maximum coagulation depth in human skin for different types of medical lasers. Lasers Surg Med 1987;7(4): 355-62.
  147. Sullins KE. Diode laser and endoscopic laser surgery. Vet Clin North Am Small Anim Pract May 2002;32(3):639-48.
  148. McKenzie AL. Physics of thermal processes in laser-tissue interaction. Phys Med Biol Sep 1990;35(9):1175-209.
  149. Reinisch L. Laser physics and tissue interaction. Otolaryngol Clin North Am Dec 1996;29(6):893-914.
  150. Coluzzi DJ. Fundamentals of dental lasers: Science and instruments. Dent Clin North Am 2004;48:751-70.
  151. Maiorana C, Salina S. Versatility of superpulsed diode laser in oral surgery: A clinical report. J Oral Laser Appl 2006;6: 193-99.
  152. Gold SI, Villardi MA. Pulsed laser beam effects on gingiva. J Clin Periodontol 1994;21:391-96.
  153. Kamp M Halbleiterlaser. Vorlesung WS 2006, Technische Physik, Uni Würzburg 2006.
  154. Schäfer O. Die Entwicklung des Diodenlasers bis zur Digitalpulstechnik. Laser Journal 2/2008:6-7.
  155. Nanami T, Shiba H, Ikeuchi S, Nagai T, Asanami S, Shibata T. Clinical applications and basic studies of laser in dentistry and oral surgery. Keio J Med Dec.1993;42(4):199-201.
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